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KMID : 0380020030180050424
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Korean Journal of Biotechnology and Bioengineering
2003 Volume.18 No. 5 p.424 ~ p.428
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Effect of Bisphenol A, Nonylphenol, Pentachlorophenol on the Proliferation of MCF-7 and PC-3 Cells
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Lee Soo-Min
Choi Hyung-Ki
Yoo Kyung-Hee
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Abstract
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In the present study, we have analyzed effects of the endocrine distruptors, such as bisphenol A, nonylphenol and pentachlorophenol, on cell proliferation in the human breast cancer cell line, MCF-7, and the human prostate cancer cell line, PC-3, with MTT method. A dose dependent analysis of the cell proliferation of MCF-7 cells after administration of bisphenol A, nonylphenol and pentachlorophenol revealed a significant induction of cell proliferation. Maximum induction of cell proliferation was observed at concentrations between 10-7/ and 10-6/ M. Whereas, these chemicals had little effect on proliferation of PC-3 cells. These results demonstrated that bisphenol A, nonylphenol and pentachlorophenol do not induce proliferation of PC-3 cells but exhibit a significant induction of MCF-7 cell proliferation, suggesting all these chemicals are a estrogen mimic.
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KEYWORD
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Endocrine disruptors, bisphenol A, nonylphenol, pentachlorophenol, cell proliferation
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